کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1185850 | 963414 | 2009 | 5 صفحه PDF | دانلود رایگان |
The methanolic extract of Garciniamangostana fruit pericarp was partitioned into butanol and water fractions in this work. Three major phenolics were purified and identified as P1 [1,3,6,7-tetrahydroxy-2,8-(3-methyl-2-butenyl) xanthone], P2 [1,3,6-trihydroxy-7-methoxy-2,8-(3-methyl-2-butenyl) xanthone] and P3 (epicatechin). Strong antioxidant activities were detected for P1–P3. In vitro cell proliferation trials indicated that P1 and P3 exhibited good immunomodulatory activities when 7.5 μg/ml was used. Furthermore, P1 and P3 showed good cytotoxicities against human breast cancer cells (MCF-7) and human colon cancer cells (LOVO). P1 exhibited the maximal cytotoxicity of 73.06% against MCF-7 cells and of 46.27% against LOVO cells when 62.5 μg/ml was used. The cytotoxicities of P1, P2, P3 and paclitaxel against normal embryonic lung fibroblast cells (HELF) were in a decreasing order: paclitaxel > P3 > P1 > P2. These results suggested that P1 and P3 could be used as a potential anticancer agent.
Journal: Food Chemistry - Volume 116, Issue 4, 15 October 2009, Pages 969–973