کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1189763 963519 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antioxidant activity of Knipholone anthrone
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Antioxidant activity of Knipholone anthrone
چکیده انگلیسی

Knipholone anthrone (KA), isolated from an Ethiopian medicinal plant, Kniphofia foliosa, Hochst (Asphodelaceae) has been shown to display a potent antiprotozoal activity and a relatively little cytotoxic effect on mammalin cells. In the present study, the antioxidant potential of KA was assessed using a variety of in vitro assay models. KA displayed a concentration-dependant scavenging effect against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The IC50 values obtained for KA and the positive control (−)-epicatechin (EC) in the DPPH assay were 22 ± 1.5 and 8.7 ± 0.9 μM (mean ± SEM; n = 3 separate experiments), respectively. KA displayed a better activity than EC in scavenging superoxide anions and preventing deoxyribose degradation by hydroxyl radicals. KA appeared to form a complex with Fe2+, displayed a concentration-dependant reducing power, and also protected (at concentrations of 4.4 μM and above) isolated DNA from damage induced by Fenton reaction-generated hydroxyl radicals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 102, Issue 4, 2007, Pages 1042–1047
نویسندگان
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