The Measurement of Charge for Induction-Based Fluidic MALDI Dispense Event and Nanoliter Volume Verification in Real Time

This study preliminarily investigates whether nanoliter volumes of concentrated polar liquids and organic monomers launched to targets using induction based fluidics (IBF) can be verified through the real time charge measurements. We show that using a nanoliter IBF dispensing device and nanocoulomb meter, charge measurements made on nanoliter drops in real time are correlated with surface area following Gauss's Law. We infer the “induction only” formation of the double layer showing the ability to determine nanoliter volumes, nearly instantaneously, in real time. We discuss the implications that these observations may have for on improving/monitoring MALDI quantitation and its quality control.

Graphical AbstractInduction Based Fluidics: Concept to measure exact nanovolumes in real time based on charge. Verified real time control can be achieved to improve quantitative MALDI.Figure optionsDownload high-quality image (118 K)Download as PowerPoint slide