کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1195341 964327 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydrogen Exchange and Mass Spectrometry: A Historical Perspective
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Hydrogen Exchange and Mass Spectrometry: A Historical Perspective
چکیده انگلیسی

Protein molecules naturally emit streams of information-rich signals in the language of hydrogen exchange concerning the intimate details of their stability, dynamics, function, changes therein, and effects thereon, all resolved to the level of their individual amino acids. The effort to measure protein hydrogen exchange behavior, understand the underlying chemistry and structural physics of hydrogen exchange processes, and use this information to learn about protein properties and function has continued for 50 years. Recent work uses mass spectrometric analysis together with an earlier proteolytic fragmentation method to extend the hydrogen exchange capability to large biologically interesting proteins. This article briefly reviews the advances that have led us to this point and the understanding that has so far been achieved.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society for Mass Spectrometry - Volume 17, Issue 11, November 2006, Pages 1481–1489
نویسندگان
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