کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1195523 964386 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Automated Sub-ppm Mass Accuracy on an ESI-TOF for Use with Drug Discovery Compound Libraries
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Automated Sub-ppm Mass Accuracy on an ESI-TOF for Use with Drug Discovery Compound Libraries
چکیده انگلیسی

An automated, routine method to obtain sub-ppm accurate mass data on a benchtop electrospray ionization time-of-flight (ESI-TOF) mass spectrometer is described. Standards in the mass range 114 to 734 Da were analyzed over a 5-day period to demonstrate intra- and interday precision and mean mass accuracy less than 1 ppm. One hundred drug discovery pharmaceutical compounds were used to demonstrate an absolute average mass accuracy of 0.47 ± 0.31 ppm. This is in contrast to previous reports of accurate mass analysis using time-of-flight mass spectrometry (TOFMS) technology that operates within 3 to 5 ppm. The same 100 samples were also analyzed using Fourier transform mass spectrometry (FTMS) technology and yielded comparable results to the TOFMS analysis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society for Mass Spectrometry - Volume 18, Issue 9, September 2007, Pages 1612–1616
نویسندگان
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