Imaging of a β-Peptide Distribution in Whole-Body Mice Sections by MALDI Mass Spectrometry

Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a β-peptide and an α-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the α-peptide control was observed at 1 h post-dose, while retention of the β-peptide was observed for longer than 24 h post-dose.