کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1199407 1493567 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemometric strategy for automatic chromatographic peak detection and background drift correction in chromatographic data
ترجمه فارسی عنوان
استراتژی شیمی برای تشخیص پیک کروماتوگرافی اتوماتیک و تصحیح رانش پس زمینه در داده های کروماتوگرافی
کلمات کلیدی
تشخیص پیک کروماتوگرافی اتوماتیک، تصحیح ریاضی سابقه، شیمی درمانی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• A new chemometric strategy for automatic chromatographic peak detection and background drift correction was developed in this study.
• It is convenient for large-scale sample analysis.
• Chromatographic peak detection and background drift correction can simultaneously be provided.

Peak detection and background drift correction (BDC) are the key stages in using chemometric methods to analyze chromatographic fingerprints of complex samples. This study developed a novel chemometric strategy for simultaneous automatic chromatographic peak detection and BDC. A robust statistical method was used for intelligent estimation of instrumental noise level coupled with first-order derivative of chromatographic signal to automatically extract chromatographic peaks in the data. A local curve-fitting strategy was then employed for BDC. Simulated and real liquid chromatographic data were designed with various kinds of background drift and degree of overlapped chromatographic peaks to verify the performance of the proposed strategy. The underlying chromatographic peaks can be automatically detected and reasonably integrated by this strategy. Meanwhile, chromatograms with BDC can be precisely obtained. The proposed method was used to analyze a complex gas chromatography dataset that monitored quality changes in plant extracts during storage procedure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1359, 12 September 2014, Pages 262–270
نویسندگان
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