کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1201296 | 1493652 | 2013 | 5 صفحه PDF | دانلود رایگان |

Chiral crown ethers have been widely used in the resolution of various chiral compounds containing a primary amino group. Covalently bonded chiral stationary phases derived from (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) were developed in our groups and utilized for the resolution for several types of analytes. By use of NMR spectroscopy, chiral discrimination studies were performed for α-amino acids and their esters using 18-C-6-TA. Here, advances in the development and application of chiral stationary phases and chiral solvating agents using 18-C-6-TA for enantiomer resolution are described in relationship to recent chiral recognition mechanism studies.
► 18-C-6-TA was found to be one of the most effective chiral selectors.
► Advances in the application of using 18-C-6-TA is described.
► (+)- and (−)-CSP 1 based on 18-C-6-TA has been successfully commercialized.
Journal: Journal of Chromatography A - Volume 1274, 25 January 2013, Pages 1–5