کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1201823 965045 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of thioketone analogues of sildenfil using gas chromatography–mass spectrometry
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Identification of thioketone analogues of sildenfil using gas chromatography–mass spectrometry
چکیده انگلیسی

Sildenafil analogues have been found adulterated in herbal preparations and food products that claim to have natural aphrodisiacs. In this study, a gas chromatography–mass spectrometry (GC–MS) assay was developed for the screening and identification of thioketone analogues of sildenafil. Thiopyrazolopyrimidine, a precursor or a cleavage product of thioketone analogue, exhibited characteristic fragment ions of m/z 328 and m/z 299 was found to be the best marker to screen the presence of general thioketone analogues. Identification by GC–MS assay was rapid and specific as all the studied thioketones showed characteristic mass fragmentations including their intact molecular ions. The developed GC–MS assay had successfully identified thiosildenafil, thiohomosildenafil and thiodimethylsildenafil in herbal preparation and food products.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1218, Issue 39, 28 September 2011, Pages 7055–7060
نویسندگان
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