Preparation and characterization of a poly(methyloctadecylsiloxane) thermally immobilized onto zirconized silica stationary phase for high-performance liquid chromatography

► HPLC support prepared by zirconization of silica. ► Stationary phase prepared by thermal immobilization of PMODS on to the support. ► Optimization of preparation by central composite design. ► Evaluation with several standardized test mixtures. ► Potential applications for separation of psychotropic drugs, xanthines and UV filters from sunscreens.