کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1203074 | 965096 | 2011 | 8 صفحه PDF | دانلود رایگان |
One of the modified simulated moving bed (SMB) processes, the intermittent SMB (I-SMB) process, has been recently analyzed theoretically [1] and its superior performance compared to the conventional SMB process has been demonstrated at a rather low total feed concentration through experiments and simulations [2]. This work shows that the I-SMB process outperforms the conventional SMB process also at high feed concentration where the species are clearly subject to a nonlinear adsorption isotherm. In the case of the separation of the Tröger's base's enantiomers in ethanol on ChiralPak AD, the two processes operated in a six-column 1-2-2-1 configuration (one column in sections 1 and 4 and two columns in sections 2 and 3) and in a four-column 1-1-1-1 configuration (one column in each section) are compared at high feed concentration through both experiments and simulations. Even under nonlinear conditions the four column I-SMB process can successfully separate the two enantiomers achieving purity levels as high as the two six column processes and exhibiting better productivity.
► We prove intermittent-SMB multicolumn chromatography under nonlinear conditions.
► The Troger's base's enantiomers have been separated on ChiralPak AD in ethanol.
► The I-SMB process outperforms the conventional SMB even at high feed concentration.
► The 4-column I-SMB process can achieve both high purity and high productivity.
Journal: Journal of Chromatography A - Volume 1218, Issue 52, 30 December 2011, Pages 9345–9352