کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1204547 1493645 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Investigation of peptoid chiral stationary phases varied in absolute configuration
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Investigation of peptoid chiral stationary phases varied in absolute configuration
چکیده انگلیسی

Based on chiral N-(1-phenylethyl) glycines, a series of peptoid chiral stationary phases (CSPs) terminated with achiral alkyl group (diisopropyl, t-butyl or n-butyl) and varied in absolute configuration of selector were investigated with nine axially chiral analytes. It is very interesting to observe that selectors with heterogeneous configuration form, such as S-R-R, S-R-S, S-S-R, generally performed better than S-S-S selectors. Moreover, longer S-R-S-R-S selector did not outperform the S-R-S one obviously, with several separations declined. In addition to the result that the elution order of most enantiomers depends on the asymmetric center adjacent to the terminus of selector, we presume that the moieties around this chiral center are the most important absorbing sites for chiral discrimination; the terminal group and other chiral blocks in selector may assist enantiorecognition by constructing appropriate conformation. Various terminal alkyl groups also resulted in a few differences in enantioselectivity.


► Peptoid CSPs varied in absolute configuration were investigated.
► Homogeneous chiral sides in peptoid selector were proved unnecessary.
► CSP with heterogeneous configuration form exhibited specific selectivity.
► The chiral residue next to the terminus was important for chiral recognition.
► Longer peptoid chain was not an essential condition for enantiorecognition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1281, 15 March 2013, Pages 155–159
نویسندگان
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