کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1205305 965190 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Theoretical advantages and drawbacks of on-line, multidimensional liquid chromatography using multiple columns operated in parallel
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Theoretical advantages and drawbacks of on-line, multidimensional liquid chromatography using multiple columns operated in parallel
چکیده انگلیسی

The theoretical advantages and drawbacks of using a multiple-, parallel column approach in on-line multidimensional liquid chromatography systems were investigated. Much time or peak capacity can be gained with the use of multiple parallel columns at the second-dimension while the aggregate time of separation increases only by the increment of the gradient time of the second-dimension. Multidimensional chromatographic systems are now used to perform many tasks ranging from routine, fast analyses to specialized, arduous separations. In this work, we focus on the advantages of a multiple, parallel columns approach to on-line multidimensional liquid chromatography systems. Calculations of the achievable peak capacities were made as functions of the number of columns operated in parallel. Increasing the number of second-dimension columns from one to two or three causes the largest increase in peak capacity with only a slight increase of aggregate time. We also present some practical aspects to consider when attempting multidimensional separations with multiple columns operated in parallel.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1216, Issue 34, 21 August 2009, Pages 6210–6217
نویسندگان
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