Preparative enantioseparations using supercritical fluid chromatography

Chromatographic enantioseparation at the preparative scale is routinely used in pharmaceutical R&D to generate individual enantiomers. Supercritical fluid chromatography (SFC) has many advantages over liquid chromatography for these separations. These advantages include rapid screening of separation conditions at the analytical scale, more rapid preparative separations, higher purification throughputs, decreased solvent consumption and waste generation and higher product concentrations post separation. SFC is a green technique which utilizes significantly less solvent compared to HPLC and can often result in reduced purification costs.

► Supercritical fluid chromatography (SFC) has many advantages over liquid chromatography for preparative resolution of enantiomers.
► SFC allows rapid screening of chiral stationary phase/mobile phase combinations.
► Preparative SFC has higher throughput, decreased solvent consumption and waste generation.
► SFC is a green technique which utilizes significantly less solvent compared to HPLC and often results in reduced purification costs.