کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1206088 1493707 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The use of quadrupole-time-of-flight mass spectrometer for the elucidation of diclofenac biotransformation products in wastewater
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
The use of quadrupole-time-of-flight mass spectrometer for the elucidation of diclofenac biotransformation products in wastewater
چکیده انگلیسی

The work presented herein discusses the potential of liquid chromatography–quadrupole-time-of-flight mass spectrometry (QqToF–MS) for the chemical structure elucidation of pharmaceutical degradation products (DPs). The model compound, the nonsteroidal anti-inflammatory drug diclofenac was subjected to microbiological transformation in a laboratory scale pilot wastewater treatment plant (WWTP) and its transformation products were detected in the outlet samples. Their chemical structures were elucidated using the principal features of the instrument, i.e. high resolution, accurate mass and MS/MS capability. A hydroxy-diclofenac, a benzoquinone imine derivative and a nitro analogue of diclofenac were successfully identified. The final structural elucidation of the fourth transformation product was not successful. Overall, the study emphasises the capabilities and potential of quadrupole-time-of-flight mass spectrometer showing it to be a powerful tool in both structure elucidation and confirming the identity of environmental contaminants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1215, Issues 1–2, 26 December 2008, Pages 57–63
نویسندگان
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