کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1207008 | 1493746 | 2007 | 8 صفحه PDF | دانلود رایگان |
In this study, a method was developed for determination of the free concentration of 4-isobutylacetophenone, a toxic degradation product of ibuprofen, in river and sewage water samples from Sweden. Sample preparation and analysis were performed by a hollow-fibre microporous membrane liquid–liquid extraction (HF-MMLLE) set-up and gas chromatography–mass spectrometry (GC–MS), respectively. In this novel approach, only the liquid in the membrane pores is utilised for non-depleting extraction. Several parameters were studied, including: type of organic solvent, sample pH, and salt and humic acid content. The optimised method allowed the determination of the analyte at the ng L−1 level in river and sewage water. A linear plot gave a correlation coefficient better than 0.992 and resulted in a limit of detection of 7 and 14 ng L−1 for river and sewage water, respectively. The enrichment factor was over 2000 in the fibre and over 300 after dilution. The repeatability and reproducibility were better than 5% and 10%, respectively. For the first time, 4-isobutylacetophenone was found at free concentrations of 40 ng L−1 or below in sewage waters, while it could not be quantified in a river downstream from a municipal sewage treatment plant.
Journal: Journal of Chromatography A - Volume 1157, Issues 1–2, 20 July 2007, Pages 30–37