کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1207893 | 1493723 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prediction of retention for sulfonamides in supercritical fluid chromatography
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Prediction of retention for sulfonamides in supercritical fluid chromatography Prediction of retention for sulfonamides in supercritical fluid chromatography](/preview/png/1207893.png)
چکیده انگلیسی
Properties-retention studies were undertaken on a test library of sulfonamides using supercritical fluid chromatography with CO2-MeOH mobile phases (in the presence or absence of additive) and a 2-ethyl-pyridyl column. Taking a restricted range of retention ratios, k (1 < k < 10) and keeping the proportion of modifier in the mobile phase, Ï, above 10%, it was shown that log k varies linearly with Ï (R2 > 0.98). From these relationships, the different retention characteristics of the analytes were calculated. Literature studies of quantitative structure-retention relationships (QSRR) showed that these characteristics can be correlated with simple molecular descriptors to derive equations predicting the retention behaviour of new compounds. Measured retention characteristics were found to correlate with total dipole moment, μ, molecular surface area, A, and the electronic charge on the most negatively charged atom, δmin. The correlation of chromatographic measurements with calculated molecular descriptors may allow the prediction of the retention behaviour for an unknown compound provided its properties are known.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1189, Issues 1â2, 2 May 2008, Pages 254-265
Journal: Journal of Chromatography A - Volume 1189, Issues 1â2, 2 May 2008, Pages 254-265
نویسندگان
Amaury Cazenave-Gassiot, Robert Boughtflower, Jeffrey Caldwell, Richard Coxhead, Laure Hitzel, Stephen Lane, Paul Oakley, Clare Holyoak, Frank Pullen, G. John Langley,