کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1208132 965292 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of magnolol and honokiol in biological fluids by capillary zone electrophoresis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Analysis of magnolol and honokiol in biological fluids by capillary zone electrophoresis
چکیده انگلیسی

Capillary zone electrophoresis (CZE) method was used for analysis of magnolol and honokiol. Under the optimized condition, CZE with UV absorption detection provided that the limit of detection was at μM level. To enhance detection sensitivity of magnolol and honokiol, CZE separation system was coupled with a laser-induced fluorescence (LIF) detector for the first time. The limits of detection of magnolol and honokiol were 12 nM (3.20 ng ml−1) and 18 nM (4.79 ng ml−1), respectively, showing that the CZE-LIF system provides greater than 100-fold sensitivity improvements than does the CZE-UV system. The developed method was applied to analyze magnolol and honokiol in spiked human plasma samples, microsome incubation samples as a preliminary demonstration of its potential in pharmacokinetic studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1142, Issue 2, 23 February 2007, Pages 240–244
نویسندگان
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