کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1208850 | 965320 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of hemoglobin adducts of acrylamide and glycidamide by liquid chromatography–electrospray ionization tandem mass spectrometry, as exposure biomarkers in French population
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
The determination of biomarkers of acrylamide exposure in humans from general French population by measurement of hemoglogin adduct levels of acrylamide (AA) and glycidamide (GA) is presented. The analytical procedure included modified Edman degradation and LC–ESI-MS/MS analysis of the final derivatives using deuterated internal standards. Method performances were evaluated in terms of linearity, precision, accuracy, and sensitivity. The method was firstly assessed on rat blood samples and then applied to the study of background adducts levels of AA and GA in 68 human hemoglobin samples, showing mean levels of 33 and 23 pmol/g globin for AA and GA adducts, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1167, Issue 2, 12 October 2007, Pages 125–134
Journal: Journal of Chromatography A - Volume 1167, Issue 2, 12 October 2007, Pages 125–134
نویسندگان
Sylvie Chevolleau, Carine Jacques, Cécile Canlet, Jacques Tulliez, Laurent Debrauwer,