کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1210477 | 965374 | 2009 | 5 صفحه PDF | دانلود رایگان |
An ultra-high-performance liquid chromatography tandem mass spectrometry method to detect residues of tetracycline (TC), epi-tetracycline (eTC) and oxytetracycline (OTC) in animal hair was developed. Hair samples were washed with water, extracted with NH4OH 0.1 M, purified by SPE-C18 cartridge and analyzed by tandem mass spectrometry (ESI+, MRM mode) with satisfactory results. For the first time, accumulation of TC, eTC and OTC was confirmed in livestock hairs after a therapeutic treatment with TC and OTC, respectively. Administered drug residues were detectable in hair samples up to 2 months after the last treatment, providing a retrospective evidence of TC and OTC administration. Hair analysis seems to offer a wider window of detection than edible tissues.
Journal: Journal of Chromatography A - Volume 1216, Issue 46, 13 November 2009, Pages 8096–8100