کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1210485 | 965374 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of benzimidazoles and levamisole residues in milk by liquid chromatography–mass spectrometry: Screening method development and validation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The screening method for the determination of residues of 19 benzimidazoles (parent drugs and their metabolites) and levamisole in bovine milk has been developed and validated. Milk samples were extracted with ethyl acetate, sample extracts were cleaned up by liquid–liquid partitioning with hexane and acidic ethanol. Liquid chromatography–single-quadrupole mass spectrometry was used for the separation and determination of analytes. The method was validated in bovine milk, according to the CD 2002/657/EC criteria. An alternative approach to the validation of the method was applied (“sum MRL” substances). The method was successfully verified in CRL proficiency test.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1216, Issue 46, 13 November 2009, Pages 8165–8172
Journal: Journal of Chromatography A - Volume 1216, Issue 46, 13 November 2009, Pages 8165–8172
نویسندگان
Piotr Jedziniak, Teresa Szprengier-Juszkiewicz, Małgorzata Olejnik,