کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1211303 | 1493758 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effect of chaotropic mobile phase additives on retention behaviour of beta-blockers on various reversed-phase high-performance liquid chromatography columns Effect of chaotropic mobile phase additives on retention behaviour of beta-blockers on various reversed-phase high-performance liquid chromatography columns](/preview/png/1211303.png)
In this study the effect of type and concentration of chaotropic counter anion in buffered mobile phase on retention behaviour of some beta-blockers was studied. Two types of anions (perchlorate, dihydrogen phosphate) were examined under different concentrations. Further different pH-values for each anion were used to investigate the effect of pH changes on chaotropic behaviour of these anions. The role of organic modifier (methanol, acetonitrile) type was also considered. All these parameters were studied for three different RP-columns (calixarene modified silica gel, monolithic RP-column and a conventional RP-column). The results indicate that all studied factors affected the chaotropic behaviour of the tested anions. Also the type of the used stationary phase has found to play an important role in retention behaviour of beta-blockers.
Journal: Journal of Chromatography A - Volume 1133, Issues 1–2, 10 November 2006, Pages 69–75