کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1211376 | 965529 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Application of high-performance liquid chromatography hyphenated techniques for identification of degradation products of cefpodoxime proxetil
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Application of the HPLC hyphenated techniques of LC–MS, LC–NMR and solvent-elimination LC–IR was demonstrated by the identification of the degradation products of a third generation cephalosporin antibiotic, cefpodoxime proxetil, in solid state, drug formulation and solution. Molecular weight and fragment information were obtained by LC–MS, and detailed structural information was confirmed by LC–NMR. Information on the carboxyl functional group obtained by solvent-elimination LC–IR was useful for confirmation of the ester hydrolysis. The degradation products were successfully identified without complicated isolation or purification processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1129, Issue 2, 6 October 2006, Pages 153–159
Journal: Journal of Chromatography A - Volume 1129, Issue 2, 6 October 2006, Pages 153–159
نویسندگان
Naoto Fukutsu, Takao Kawasaki, Koichi Saito, Hiroyuki Nakazawa,