کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1213468 1494136 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study
چکیده انگلیسی
► A selective, rapid and sensitive UPLC/MS method was developed and validated to quantitate a highly selective mixed-affinity sigma receptor ligand. ► The validated analytical method resulted in a run time of 4 min. The calibration curve exhibited excellent linearity over a concentration range of 5-4000 ng/mL (LLOQ, 5 ng/mL). The intra- and inter-day precision values were below 15% and accuracy ranged from −6.5% to 5.0%. ► The validated method was successfully applied to an intravenous pharmacokinetic study of CM156 in rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volumes 891–892, 1 April 2012, Pages 1-6
نویسندگان
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