کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1214417 966932 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lipid-based biomarkers for cancer
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Lipid-based biomarkers for cancer
چکیده انگلیسی

Lipids play important and diverse roles in cells. Most obvious functions are storage of chemical energy, provision of structural support of biological membranes and signaling. All these cellular processes are of critical relevance to cells which undergo transformation, cancer progression and metastasis. Thus, it is likely that certain classes of lipids are reflective for the cellular physiology in cancer cells and tissue. Here we discuss key roles of lipids involved in cancer as well as challenges for development of novel lipid-based biomarkers. Special emphasis will be given to mass spectrometry based analysis of lipids. Such technology has been successfully used for qualitative and quantitative analysis of lipids with very different chemistries. Comparative analysis, often in case–control regimes, and either in non-targeted (e.g. by liquid chromatography–single stage mass spectrometry) or targeted (i.e. by tandem mass spectrometry) fashion yields vast arrays of information. Uni-variate (such as Student's t-test or Mann–Whitney U-test) and multivariate statistics (principal components analysis, machine learning and regression analysis) are next used to identify variations in individual lipid species and/or to lower dimensions for visualization and grouping of cases and controls. As a result surrogate (single or multi-parameter) markers are identified which form the basis for functional validation as well as potential translation to alternative analytical readouts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 877, Issue 26, 15 September 2009, Pages 2830–2835
نویسندگان
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