کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1214961 966957 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cysteine-based chiral selectors for the ligand-exchange separation of amino acids
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Cysteine-based chiral selectors for the ligand-exchange separation of amino acids
چکیده انگلیسی

Three cysteine-based coated selectors, S-benzyl-(R)-cysteine, S-diphenylmethyl-(R)-cysteine and S-trityl-(R)-cysteine, have been used in the ligand-exchange separation of a selected set of natural and unnatural underivatized amino acids. With only few exceptions, a gain in enantiodiscrimination was obtained when the most lipophilic discriminating agent, characterized by the presence of a trityl moiety, was engaged. Moreover, a new descriptive structure–separation relationship study through molecular surface (Jurs) and shape (Shadow) descriptors provided evidence that specific physico-chemical features of the employed chiral selector result decisive in establishing which property of the analyte is responsible for the enantiorecognition accomplishment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 875, Issue 1, 1 November 2008, Pages 108–117
نویسندگان
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