کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1215021 | 966959 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Searching biomarker candidates in serum using multidimensional native chromatography. II Method evaluation with Alport syndrome and severe inflammation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Biomarker search using multidimensional native liquid fractionation of serum in microplates was evaluated. From different donors, homologous sample fractions with UV absorbance depending on state of illness were selected, and their constituents were identified and quantitated by MS. Analysis of sera of patients with Alport syndrome and severe inflammation proved the reliability of the method by confirming characteristic alterations. Moreover, 23 new marker candidates were detected for Alport syndrome, some of them being involved in matrix degradation and repair, and 33 new candidates for severe inflammation, among them α1B-glycoprotein cysteine-rich secretory protein and an apparently low molecular-weight albumin variant.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 876, Issue 1, 1 December 2008, Pages 31–40
Journal: Journal of Chromatography B - Volume 876, Issue 1, 1 December 2008, Pages 31–40
نویسندگان
Adrienne Baum, Michael Pohl, Stefan Kreusch, Gerhard A. Cumme, Günter Ditze, Joachim Misselwitz, Michael Kiehntopf, Lene Udby, Andreas Meier-Hellmann, Heidrun Rhode,