کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1215151 | 966965 | 2008 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A high-performance liquid chromatography–tandem mass spectrometry method for the clinical combination study of carboplatin and anti-tumor agent eribulin mesylate (E7389) in human plasma
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A high-performance liquid chromatography–tandem mass spectrometry method for the clinical combination study of carboplatin and anti-tumor agent eribulin mesylate (E7389) in human plasma A high-performance liquid chromatography–tandem mass spectrometry method for the clinical combination study of carboplatin and anti-tumor agent eribulin mesylate (E7389) in human plasma](/preview/png/1215151.png)
چکیده انگلیسی
An LC/MS/MS method was developed to quantify carboplatin and eribulin mesylate (E7389) in human plasma and urine. For carboplatin, sample clean-up by protein precipitation and supernatant injection into a Waters Spherisorb® S5 SCX column was used. Liquid-phase extraction and reverse-phase chromatography on a Polaris® C18 column were used for eribulin. Quantitation involved LC/MS/MS with positive electrospray ionization. Accuracy, precision, linearity, range, specificity, recovery and stability were also evaluated. Both compounds were stable in human plasma (≥80 days at −80 °C), at room temperature (≥4 h), following three freeze–thaw cycles and in 50/50 methanol/H2O (<4 °C for ≥252 days).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 875, Issue 2, 15 November 2008, Pages 373–382
Journal: Journal of Chromatography B - Volume 875, Issue 2, 15 November 2008, Pages 373–382
نویسندگان
Christopher DesJardins, Phil Saxton, Sharon X. Lu, Xiaofang Li, Christopher Rowbottom, Y. Nancy Wong,