کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1215404 | 1494181 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effective separation and simultaneous determination of seven fluoroquinolones by capillary electrophoresis with diode-array detector
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A simple, rapid and accurate method has been developed for effective separation and simultaneous determination of lomefloxacin, gatifloxacin, enoxacin, ciprofloxacin, ofloxacin, enrofloxacin and pefloxacin residues in porcine tissue by capillary electrophoresis with diode-array detector. The separation conditions were investigated and optimized. The sample was extracted with acetonitrile, and a mixture consisted of 25Â mM NaH2PO4, 25Â mM Na2B4O7 and 25Â mM H3BO3 (pH 9.0) was used as a running buffer. A linear relationship between concentration and peak area for each compound was obtained in the concentration range of 0.5-100Â mg/L with a correlation coefficient greater than 0.9994. For analysis of porcine tissue, the detection limits of lomefloxacin, gatifloxacin, enoxacin, ciprofloxacin, ofloxacin, enrofloxacin and pefloxacin were 0.013, 0.012, 0.023, 0.040, 0.037, 0.035 and 0.034Â mg/kg, respectively. The recoveries are in the range of 72-93%. The intra-day precision is less than 5%, and the inter-day precision is less than 10%. The proposed method has high resolution, speed and the extremely small sample volume required. It can permit to confirm the presence of the studied seven fluoroquinolones in porcine tissue at the required maximum residue limit (MRL) level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 852, Issues 1â2, 1 June 2007, Pages 145-151
Journal: Journal of Chromatography B - Volume 852, Issues 1â2, 1 June 2007, Pages 145-151
نویسندگان
Han-wen Sun, Pan He, Yun-kai Lv, Shu-xuan Liang,