کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1215846 966984 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Traces of phosgene in chloroform: Consequences for extraction of anthracyclines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Traces of phosgene in chloroform: Consequences for extraction of anthracyclines
چکیده انگلیسی

Chloroform is commonly used to extract anthracyclines from various biological matrices. However, their determination can be seriously compromised by phosgene traces present as a result of failing stabilization of chloroform. Out of the three varieties in which chloroform exists (not stabilized, stabilized with an alcohol and stabilized with a hydrocarbon) only the ethanol stabilized type minimizes chances on creating artifacts. Chromatographic separation after extraction of four anthracyclines (doxorubicin, epirubicin, daunorubicin and idarubicin) and two metabolites (13-S-dihydrodoxorubicin and 13-S-dihydroepirubicin) with chloroform under various conditions indicate that the appropriate choice of stabilizer in this extraction solvent is highly relevant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 848, Issue 2, 1 April 2007, Pages 384–390
نویسندگان
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