کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1215864 | 966985 | 2007 | 6 صفحه PDF | دانلود رایگان |
A GC–MS method for the simultaneous determination of hexanal, heptanal, octanal, nonanal and decanal in exhaled breath was established and validated. The aldehydes were derivatized on PDMS/DVB fibres using O-2,2,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride (PFBHA) as the headspace derivatization reagent. The resultant oximes were quantified by GC–MS in selected ion monitoring (SIM) mode. The method provides detection limits of 0.01–0.03 nM for the aldehydes, with a linear response in the concentration range 0.002–20 nM. Within-day precision values for the five aldehydes at 0.02–0.04 nM and 0.2–0.4 nM were in the ranges: 3–9% and 3–8%, respectively; the corresponding between-day precision values were 11–22% and 10–24%. Exhaled breath samples could be stored at −20 °C for 48 h.
Journal: Journal of Chromatography B - Volume 860, Issue 1, 1 December 2007, Pages 86–91