کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1215938 966988 2007 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Scale-up of monoclonal antibody purification processes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Scale-up of monoclonal antibody purification processes
چکیده انگلیسی

Mammalian cell culture technology has improved so rapidly over the last few years that it is now commonplace to produce multi-kilogram quantities of therapeutic monoclonal antibodies in a single batch. Purification processes need to be scaled-up to match the improved upstream productivity. In this chapter key practical issues and approaches to the scale-up of monoclonal antibody purification processes are discussed. Specific purification operations are addressed including buffer preparation, chromatography column sizing, aggregate removal, filtration and volume handling with examples given.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 848, Issue 1, 15 March 2007, Pages 64–78
نویسندگان
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