کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1216253 | 1494163 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancer
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancer Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancer](/preview/png/1216253.png)
چکیده انگلیسی
Protein patterns of 129 Helicobacter pylori strains isolated from Korean and Colombian patients suffering from duodenal ulcer or gastric cancer were analyzed by the high-throughput methodology SELDI-TOF-MS. Eighteen statistically significant candidate biomarkers discriminating between the two clinical outcomes were selected by using the Mann–Whitney test. Three biomarker proteins were purified and identified as a neutrophil-activating protein NapA (HU HPAG1_0821), a RNA-binding protein (HPAG1_0813), and a DNA-binding histone-like protein HU, respectively (jhp0228). These novel biomarkers can be used for development of diagnostic assays predicting the evolution to gastric cancer in H. pylori-infected patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 877, Issues 11–12, 15 April 2009, Pages 1193–1199
Journal: Journal of Chromatography B - Volume 877, Issues 11–12, 15 April 2009, Pages 1193–1199
نویسندگان
Ghalia Khoder, Yoshio Yamaoka, Jean-Louis Fauchère, Christophe Burucoa, Christo Atanassov,