کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1216853 1494173 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of a reference material using methamphetamine abusers’ hair samples for the determination of methamphetamine and amphetamine in hair
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Development of a reference material using methamphetamine abusers’ hair samples for the determination of methamphetamine and amphetamine in hair
چکیده انگلیسی

In the present study, we developed a reference material (RM) using authentic hair samples for the determination of methamphetamine (MA) and its main metabolite, amphetamine (AP) in human hair. MA abusers’ hair samples were collected, homogenized and finally bottled. The concentration of each bottle was determined using two extraction methods, agitation with 1% HCl in methanol at 38 °C and ultrasonication with methanol/5 M HCl (20:1), followed by gas chromatography/mass spectrometry (GC–MS) after derivatization with trifluoroacetic anhydride (TFAA). Both analytical procedures were fully validated and their extraction efficiency was compared. The homogeneity of analytes was evaluated and their property values were determined with their uncertainties. The two methods were acceptable to analyze MA and AP in human hair through the validation and comparative studies using spiked and authentic hair samples as well as NIST SRM 2379 certified reference material. Satisfying homogeneity was reached for MA and AP in the prepared RM. Finally, a human hair RM containing MA and AP is prepared at the level of 7.64 ± 1.24 and 0.54 ± 0.07 ng/mg, respectively. This material can be useful in forensic laboratories for internal quality control and external quality assurance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 865, Issues 1–2, 1 April 2008, Pages 33–39
نویسندگان
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