کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1217289 | 967083 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Surface energetics of bone mineral and synthetic hydroxyapatite using inverse gas chromatography
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Surface energy is one of the important factors that govern protein adhesion and cell attachment on biomaterial surfaces. Inverse gas chromatography (IGC) provides an excellent method to measure the surface energetics of rough and porous biosurfaces. In this study IGC was used to characterize and compare the surface energetics of synthetic and biological hydroxyapatites (natural bone mineral). IGC experiments were performed on three samples: synthetic hydroxyapatites with two levels of purity (99% and 90%) and natural biological hydroxyapatite obtained from bovine trabecular bone. The Lifshitz-Van der Waals component of the surface free energy (γSLW) and specific interaction parameter (ÉÏ) were determined by using homologous series of n-alkanes and alkenes as IGC probe molecules, respectively. The synthetic hydroxyapatite had values of γSLW of 33.4 mJ mâ2 at 99% purity and 53.3 mJ mâ2 at 90% purity. Biological hydroxyapatite had a value of γSLW of 45.7 mJ mâ2. For the synthetic hydroxyapatite, the values of Ï-bond specific interaction parameters, ÉÏ, were 0.95 mJ (99%) and 3.01 mJ (90%). The biological hydroxyapatite sample had a value of 2.44 mJ for ÉÏ. The results suggest that, as compared to the synthetic compounds, the biological apatite has considerable surface heterogeneity, either chemical (impurities) or structural suggesting a scaffold surface that is more conducive of protein adhesion and cell attachment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 879, Issue 21, 1 July 2011, Pages 1847-1850
Journal: Journal of Chromatography B - Volume 879, Issue 21, 1 July 2011, Pages 1847-1850
نویسندگان
Bhushan B. Hole, D. Steven Keller, William M. Burry, James A. Schwarz,