کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1217977 | 967182 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of emerging techniques in the investigation of prolidase deficiency: From diagnosis to the development of a possible therapeutical approach
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
The aim of the present article is to review the efforts performed in the past two decades by numerous research groups for the development of methods that allow a correct diagnosis of prolidase deficiency (PD), a rare autosomal recessive disorder and for the rationalization of a possible therapeutic intervention on these patients. In particular, the interest of the reader is focused on the application of capillary electrophoresis (i) for the detection of biological markers that reflect the pathological feature of the disease and (ii) for the determination of the efficiency of a carrier system in delivering prolidase inside cells in a possible therapy based on enzyme replacement.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 832, Issue 1, 17 February 2006, Pages 1–8
Journal: Journal of Chromatography B - Volume 832, Issue 1, 17 February 2006, Pages 1–8
نویسندگان
Simona Viglio, Laura Annovazzi, Bice Conti, Ida Genta, Paola Perugini, Chiara Zanone, Begoña Casado, Giuseppe Cetta, Paolo Iadarola,