کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1219581 967720 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fish skin gelatin hydrolysates as dipeptidyl peptidase IV inhibitors and glucagon-like peptide-1 stimulators improve glycaemic control in diabetic rats: A comparison between warm- and cold-water fish
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Fish skin gelatin hydrolysates as dipeptidyl peptidase IV inhibitors and glucagon-like peptide-1 stimulators improve glycaemic control in diabetic rats: A comparison between warm- and cold-water fish
چکیده انگلیسی


• Warm-water fish skin gelatin contains high amounts of imino acids.
• Warm-water fish skin gelatin hydrolysates have great DPP-IV inhibitory activity.
• Six isolated peptides comprised Pro as the second N-terminal residue.
• HSGH and TSGH inhibited plasma DPP-IV activity and induced GLP-1 secretion.
• TSGH improved the glycaemic control better than HSGH in diabetic rats.
• The protein with high imino acid content had the potential to improve diabetes.

Various warm- and cold-water fish skins were used to prepare gelatin hydrolysates and compare their in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory activity. The DPP-IV inhibitory activity of gelatin hydrolysates from warm-water fish was greater than that from cold-water fish. The <1.5 kDa ultrafiltration fractions obtained from halibut skin hydrolysate (HSGH) and tilapia skin gelatin hydrolysate (TSGH) displayed in vitro DPP-IV inhibitory activity of 38.2 and 51.9% at a sample concentration of 1 mg solid/mL, respectively, and they were used for in vivo antihyperglycaemic experiment. The daily administration of TSGH for 30 days was more potent to improve the glucose tolerance in streptozotocin-induced diabetic rats than that of HSGH due to the inhibition of plasma DPP-IV activity, enhancement of glucagon-like peptide-1 (GLP-1) and insulin secretion. Therefore, the warm-water fish skin gelatin, rich in imino acids, has the potential to be the precursor of DPP-IV inhibitor for improvement of diabetes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 19, Part A, December 2015, Pages 330–340
نویسندگان
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