کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1219605 967720 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anticancer activities of anthocyanin extract from genotyped Solanum tuberosum L. “Vitelotte”
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Anticancer activities of anthocyanin extract from genotyped Solanum tuberosum L. “Vitelotte”
چکیده انگلیسی


• Molecular genotyping of Vitelotte potato was identified promoting the use of this genetic resource by plant breeders.
• Molecular analyses of anthocyanin action in cancer revealed modulation of cell cycle regulators.
• Anthocyanin extract inhibited Akt-mTOR signalling inducing maturation of acute myeloid leukaemia cells.

The action of anthocyanins contained in the Vitelotte potato (Solanum tuberosum L.) in both breast and haematological cancers were investigated. The biomedical activities of anthocyanin extract derived from the Vitelotte cultivar were determined. Molecular genotyping was performed to properly identify this outstanding genotype in comparison to other potato varieties and to promote the utilization of this genetic resource by plant breeders. Furthermore, cellular and molecular characterization of the action of anthocyanin extract in cancer cells revealed that modulation of cell cycle regulators occurs upon treatment. As well as inducing apoptotic players such as TRAIL in cancer systems, anthocyanin extract inhibited Akt-mTOR signalling thereby inducing maturation of acute myeloid leukaemia cells. These results are of interest in view of the impact on food consumption and as functional food components on potential cancer treatment and prevention.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 19, Part A, December 2015, Pages 584–593
نویسندگان
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