کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1220287 1494622 2015 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analytical methodologies for the determination of benzodiazepines in biological samples
ترجمه فارسی عنوان
روش های تحلیلی برای تعیین بنزودیازپین ها در نمونه های بیولوژیکی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Physicochemical and pharmacological properties of commonly used benzodiazepines.
• Review of biological sample preparation techniques for benzodiazepine analysis.
• Review of methodology for the determination of benzodiazepines in biological matrices.

Benzodiazepine drugs belong to important and most widely used medicaments. They demonstrate such therapeutic properties as anxiolytic, sedative, somnifacient, anticonvulsant, diastolic and muscle relaxant effects. However, despite the fact that benzodiazepines possess high therapeutic index and are considered to be relatively safe, their use can be dangerous when: (1) co-administered with alcohol, (2) co-administered with other medicaments like sedatives, antidepressants, neuroleptics or morphine like substances, (3) driving under their influence, (4) using benzodiazepines non-therapeutically as drugs of abuse or in drug-facilitated crimes. For these reasons benzodiazepines are still studied and determined in a variety of biological materials. In this article, sample preparation techniques which have been applied in analysis of benzodiazepine drugs in biological samples have been reviewed and presented. The next part of the article is focused on a review of analytical methods which have been employed for pharmacological, toxicological or forensic study of this group of drugs in the biological matrices. The review was preceded by a description of the physicochemical properties of the selected benzodiazepines and two, very often coexisting in the same analyzed samples, sedative-hypnotic drugs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 113, 10 September 2015, Pages 239–264
نویسندگان
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