Preparation method modulates hypocholesterolaemic responses of potato peptides

The hypocholesterolaemic ability of two potato peptide preparations in rats was compared. Experimental groups were fed for 4 weeks, with casein as the basal diet, in comparison with two diets containing 20% potato peptide preparations PPS (short hydrolysis preparation; 16 h) and PPL (long hydrolysis preparation; 25 h). Serum total cholesterol and serum triacylglycerol levels were lower in PPS-fed group compared with CN- and PPL-fed groups. Lower non-HDL cholesterol level (P < 0.05) in both PPS- and PPL-fed groups, was followed by higher neutral sterol excretion, and higher hepatic LDL-R and SR-B1 mRNA level than the control. Hepatic SREBP-2 and HMG-CoA reductase mRNA level were higher in PPL-fed group compared with the CN-fed group (P < 0.05). Caecal total SCFA concentration was higher in PPL-fed group relative to PPS- and CN-fed groups. Based on these data, it could be suggested that the difference in the preparation method may modulate the hypocholesterolaemic responses of potato peptides in rats.