Separation and structural elucidation of a new tadalafil analogue diethylaminopretadalafil included as an adulterant in a dietary supplement

• In the present study, a new tadalafil analogue as an adulterant in a dietary supplement was detected and isolated.
• The structure of the new analogue was elucidated by means of NMR, HPLC and mass spectroscopy.
• The possible origination of the new analogue was also proposed here.
• The structure of this analogue was identified and reported for the first time.

A new tadalafil analogue was detected and isolated from a dietary supplement, the structure was elucidated by means of nuclear magnetic resonance (NMR) and mass spectroscopy. The compound was determined to be diethylaminopretadalafil, which might be derived from a precursor in the synthesis of tadalafil.

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