کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1220498 | 967787 | 2009 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Attenuation of iNOS and COX2 by blueberry polyphenols is mediated through the suppression of NF-κB activation Attenuation of iNOS and COX2 by blueberry polyphenols is mediated through the suppression of NF-κB activation](/preview/png/1220498.png)
Treatment of BV2 microglial cells with blueberry extracts has been shown to be effective in reducing lipopolysaccharide (LPS)-induced proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), inducible NO synthase (iNOS), and cyclooxygenase 2 (COX2). The current study explored the possibility that the down-regulation of iNOS and COX2 by blueberry extracts was mediated through NF-κB signaling pathway. A column-purified fraction of polyphenol-enriched blueberry extract (PC18) was used to treat LPS-activated BV2 cells. The results thus far showed that blueberry polyphenols significantly suppressed iNOS and COX2 promoter activities. In addition, blueberry polyphenols inhibited NF-κB nuclear translocation in LPS-activated BV2 cells. These findings suggested that the beneficial effects of blueberries may involve direct modulation of oxidative stress and/or inflammatory signaling cascades.
Journal: Journal of Functional Foods - Volume 1, Issue 3, July 2009, Pages 274–283