کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1221181 967815 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of oxidative degradation impurities of Olanzapine drug substance as well as drug product
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Identification of oxidative degradation impurities of Olanzapine drug substance as well as drug product
چکیده انگلیسی

Impurities found in stressed and stability studies of Olanzapine (polymorphic form-I) [1], [2], [3], [4], [5], [6] and [7] in both drug substance and drug product are described. These impurities are identified as 4-(4-methyl-1-piperazinyl)-3-hydroxymethylidene-1H-benzo[b][1,4]diazepine-2(3H)-thione (hydroxymethylidene thione) and (Z)-4-(4-methyl-1-piperazinyl)-3-acetoxymethylidene-1H-benzo[b][1,4]diazapine-2(3H)-thione (acetoxymethylidene thione). An oxidative degradation pathway of Olanzapine, for the formation of these impurities, has been proposed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 56, Issue 2, 10 September 2011, Pages 413–418
نویسندگان
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