کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1221449 1494658 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proteomics-based identification of plasma biomarkers in oral squamous cell carcinoma
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Proteomics-based identification of plasma biomarkers in oral squamous cell carcinoma
چکیده انگلیسی

Oral squamous cell carcinoma (OSCC) is an aggressive cancer and its occurrence is closely related to betel nut chewing in Taiwan. However, there are few prognostic and diagnostic biomarkers for this disease especially for its association with betel nut chewing. Recent progresses in quantitative proteomics have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and for understanding the molecular mechanisms of OSCC. In present study, plasma samples from OSCC patients with at least 5-year history of betel nut chewing and healthy donors were analyzed by fluorescence 2D-DIGE-based proteomic analysis. Totally, 38 proteins have been firmly identified representing 13 unique gene products. These proteins mainly function in inflammatory responses (such as fibrinogen gamma chain) and transport (Apolipoprotein A–I). Additionally, the current quantitative proteomic approach has identified numerous OSCC biomarkers including fibrinogen (alpha/beta/gamma) chain, haptoglobin, leucine-rich alpha-2-glycoprotein and ribosomal protein S6 kinase alpha-3 (RSK2) which have not been reported and may be associated with the progression and development of the disease. In summary, this study reports a comprehensive patient-based proteomic approach for the identification of potential plasma biomarkers in OSCC. The potential of utilizing these markers for screening and treating OSCC warrants further investigations.

Figure optionsDownload as PowerPoint slideHighlights
► Oral squamous cell carcinoma (OSCC) is an aggressive cancer closely related to betel nut chewing.
► Quantitative proteomics have offered opportunities to discover plasma OSCC protein biomarkers.
► This study identified numerous unreported OSCC markers such as RSK2.
► The utilization of these markers for screening and treating OSCC warrants further investigations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 75, 5 March 2013, Pages 7–17
نویسندگان
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