کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1221605 | 967835 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of aqueous stability and degradation products of series of coumarin dimers
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
The stability in aqueous solution of five classes of coumarin dimers (I–V, compounds 1–29) was studied by HPLC–MS/MS at various pH values. The relationship between chemical structure and stability is discussed. It was found that dimeric compounds with strong electron withdrawing groups (EWGs) on the α-carbon to the bridging C-atom are stable at all pH values, whereas other derivatives undergo retro-Michael addition at rates which are also affected by the substituents on the aromatic rings. In some cases formation of stable isomers or oxidation products was observed. In order to evaluate their developability and potential for progression to in vivo studies, representative compounds were tested in an in vitro microsomal stability assay.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 54, Issue 1, 5 January 2011, Pages 37–47
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 54, Issue 1, 5 January 2011, Pages 37–47
نویسندگان
Snježana Dragojević, Vitomir Šunjić, Vlatka Bencetić-Mihaljević, Jovica Ralić, Milan Mesić, Ivaylo Jivkov Elenkov, Anita Filipović Sučić, Andreja Čempuh Klonkay, Lidija Lerman, Marina Ilijaš, Vesna Gabelica-Marković, Ivica Malnar,