کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1221605 967835 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determination of aqueous stability and degradation products of series of coumarin dimers
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Determination of aqueous stability and degradation products of series of coumarin dimers
چکیده انگلیسی

The stability in aqueous solution of five classes of coumarin dimers (I–V, compounds 1–29) was studied by HPLC–MS/MS at various pH values. The relationship between chemical structure and stability is discussed. It was found that dimeric compounds with strong electron withdrawing groups (EWGs) on the α-carbon to the bridging C-atom are stable at all pH values, whereas other derivatives undergo retro-Michael addition at rates which are also affected by the substituents on the aromatic rings. In some cases formation of stable isomers or oxidation products was observed. In order to evaluate their developability and potential for progression to in vivo studies, representative compounds were tested in an in vitro microsomal stability assay.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 54, Issue 1, 5 January 2011, Pages 37–47
نویسندگان
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