Identification of new synthetic PDE-5 inhibitors analogues found as minor components in a dietary supplement

• Three new sildenafil analogues were found in a single dietary supplement.
• Isonitrosoprodenafil, dithiodesethylcarbodenafil, norcarbodenafil.
• They originate from at least two different synthetic routes.

A dietary supplement sold in erotic shops was analysed. It contains dithiodesmethylcarbodenafil as the major component, which was already reported as an adulterant in dietary supplements. Additionally three more compounds were found and their structures were elucidated after isolation using NMR and mass spectroscopy. They were designated as isonitrosoprodenafil, dithiodesethylcarbodenafil and norcarbodenafil.

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