کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1221772 | 1494643 | 2014 | 4 صفحه PDF | دانلود رایگان |
• We identify four degradation products of cefpirome sulfate (CPS) by a hybrid ESI-Q-TOF mass spectrometer.
• We estimate influence of temperature and relative air humidity (RH) on the stability of CPS.
• We calculate kinetic and thermodynamic parameters of degradation of CPS in a solid state.
The process of degradation was studied by using an HPLC-DAD method. Four degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of cefpirome sulfate was investigated. In the solid state the degradation of cefpirome sulfate was a first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated.
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Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 92, 15 April 2014, Pages 22–25