کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1221824 1494669 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flow injection photometric determination of NaCl, KCl and glucose in injectable drugs exploiting Schlieren signals
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Flow injection photometric determination of NaCl, KCl and glucose in injectable drugs exploiting Schlieren signals
چکیده انگلیسی

A flow injection photometric system that exploits Schlieren signals for analytical measurement is described. The system was designed to be used as a new strategy for determining the contents of sodium chloride, potassium chloride and glucose, each respectively in injectable drugs. The proposed methodology was based on the difference between the refractive indices of the sample zone and of the carrier stream. With this perspective, a lab-made photometer based on LED-phototransistor technology was employed as a detection system to investigate the different analytical profiles related to the Schlieren effect in low flow rate conditions. The parameters of the flow system, such as flow-rate, optical path length, and sampling loop, were adjusted in order to obtain suitable Schlieren profiles for the measurements. Data evaluation was performed with the application of partial least squares regression (PLS-1). The obtained results demonstrated the predictive ability of the constructed PLS models, and the predicted concentration values were in agreement with the reference values, with a 95% confidence level.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 62, 25 March 2012, Pages 172–176
نویسندگان
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