کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1222170 1494666 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of counterfeit Cialis® tablets using Raman microscopy and multivariate curve resolution
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Analysis of counterfeit Cialis® tablets using Raman microscopy and multivariate curve resolution
چکیده انگلیسی

Counterfeit medicines have become a serious global problem. Consequently, analytical and pharmaceutical scientists have been active in developing and applying new methodologies to detect and analyze counterfeit medicines. Vibrational spectroscopy combined with chemometric methods is becoming a popular choice in this area of research. In this study, Raman microscopy was used to collect chemical images of counterfeit tadalafil tablets and multivariate curve resolution (MCR) was used to analyze the Raman spectra and reveal the identities of the excipients and active pharmaceutical ingredients (API) in each tablet. Resolved counterfeit tablet spectra were compared to the resolved genuine tablet spectra. Both similarities and dissimilarities were revealed by the analysis in terms of the identity of the excipients, the quantity of the API, and the distribution of the components. It was concluded that Raman microscopy combined with MCR is a powerful method to detect and analyze counterfeit tablets.


► Counterfeit Cialis tablets were analyzed using Raman microscopy and multivariate curve resolution (MCR).
► Excipients and API can be resolved by this technique and chemical maps were obtained to show the spatial distribution of components.
► MCR reveals subtle differences between genuine and counterfeit tablets.
► Raman microscopy combined with MCR provides chemical insights to the analysis of counterfeit medicines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 66, July 2012, Pages 126–135
نویسندگان
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