کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1222266 967859 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural elucidation of the Rifaximin Ph. Eur. Impurity H
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Structural elucidation of the Rifaximin Ph. Eur. Impurity H
چکیده انگلیسی

Rifaximin, a semisynthetic, rifamycin-based non-systemic antibiotic is used in the treatment of acute and chronic gastrointestinal disorders. The aim of this study was the elucidation of the molecular structure of the 802 Dalton impurity which was found in Rifaximin industrial batches and reported with an erroneous structure in European Pharmacopoeia 6.5 (2009) [7] monograph as Rifaximin Impurity H. This impurity was isolated from Rifaximin by preparative HPLC and purified by column chromatography. The molecular structure was evidenced by means of 1H and 13C NMR spectroscopy, mass spectrometry and FT-IR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 51, Issue 4, 11 March 2010, Pages 858–865
نویسندگان
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